VITVO 3D Cell Culture Bioreactor

Our VITVO 3D Bioreactor enables an in vitro reconstruction of tissue complexity in an in vivo-like environment.

  • Fiber-based 3D scaffold
  • A combination of in vitro and in vivo techniques
  • Simplify drug testing, histological analysis, and animal studies
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Three Dimensional Platform

Three dimensional (3D) platforms have potential to provide more physiologic environments for cell culture in drug discovery and toxicology than classical 2D culture systems.

VITVO-1140

A Different Modulation of Gene Expression

The 3D culture of VITVO leads to a different modulation of gene expression, ultimately influencing the antigenic profile of the cells and closely mimicking an in vivo environment.

Overview

Features & Benefits

  • 3D cultures retain the advantage to mimic an in vivo-like context enabling drug safety and efficacy testing in a human avatar environment
  • Fast read-out without the need of a dedicated device (tray fits into a multi-well luminometer)
  • Ability to host multiple cell types simultaneously loaded in the two faces
  • Can host multiple cell types in a minimal volume
  • Respects the biology of the tumor (i.e. antigen expression)
  • Ideal for small scale studies
  • Portability
  • Short-duration use

Applications

To address chemotherapy/TKI efficacy in 3D To minimize animal uses (3R)

  • To address cell therapies efficacy (possibility to load Targets and Effectors at variable ratios in a 3D relevant model CAR-T, MSC)
  • To address biologics efficacy in 3D (PD/PK), i.e tumor penetration of a monoclonal antibody
  • To address putative drug toxicity in 3D (hepatocytes)
  • To host tumor spheroids (Glioblastoma) also loaded in the two faces
  • Cancer metabolomics (i.e. tumor/stroma interaction)
  • Histology testing after cell loading (methacrylate embedding)
  • Histology testing after cytotoxicity (surrogate of minimal residual disease)
  • Migration assays in 3D
  • As well as many other applications

Video

Technical Specs

Material Device Frame: TPE
3D Matrix: hydrophilically coated PBT
Oxygenation Membranes: PMP
Size Matrix volume: 4 cm2 (area) x 400 µm (thickness)
Empty volume: 90% of matrix volume
Production The automated fabrication is performed in the clean room, by the innovative technology without any additives and gluing agents
Biological safety Inert, biocompatible and xeno-free
DNAse/RNAse free
Sterilization Electron-beam processing
Storage and warehousing Two years shelf life

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